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Gastrointestinal conditions Some gastrointestinal conditions may affect how vitamin B12 is digested or absorbed, such as: history of gastrointestinal surgery celiac disease Crohns disease pernicious anemia infections, such as from Helicobacter pylori bacteria or parasites pancreatic insufficiency or cancer bowel cancer folic acid deficiency small intestinal bacterial overgrowth Vitamin B12 injections may be more helpful for people with gastrointestinal conditions than oral products

Why it happens: Retatrutide includes glucagon receptor activation, which has metabolic effects including slight heart rate increase

For pernicious anaemia, maintenance injections are typically given every 2-3 months lifelong

One -CA has been reported to prefer Mn II over Zn II , although the extent to which this is broadly the case is not known