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10.1016/j.ejphar.2024.176406 79 LiuZ

Hamed K, Alosaimi MN, Ali BA, Alghamdi A, Alkhashi T, Alkhaldi SS et al (2024) Glucagon-like peptide-1 (GLP-1) receptor agonists: exploring their impact on diabetes, obesity, and cardiovascular health through a comprehensive literature review

Published studies suggest retatrutide produced larger mean body-weight reductions at top reported doses than tirzepatide in cohorts with obesity, although direct head-to-head trials have not been published at time of writing

Finally, this article may overly emphasize the technical capabilities of AI and metabolomics, while lacking depth in exploring the fundamental challenges currently existing, such as the quality of omics data and the complexity of drug mechanisms