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Based on the fact that the carboxyl moiety of ibuprofen binds to Arg-120 and Tyr-355 without extending into the side pocket, it was hypothesized that making the carboxyl group longer by adding larger, more rigid groups with hydrogen-bonding functions could enhance the selectivity of ibuprofen while maintaining its ability to reduce pain and inflammation

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Most stomach or intestinal complaints are best treated orally

Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice