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Growth hormone (somatropin) itself is a controlled drug under the Misuse of Drugs Act 1971 Class C, Schedule 4 Part II

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Clinical evidence links elevated HKII expression to advanced CRC features including tumor volume, invasion depth, staging, and lymph node metastasis, establishing its dual role as both a prognostic marker and therapeutic target

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In validation experiments, the MS-HRM assay showed better sensitivity than the MethyLight assay (Wojdacz and Dobrovic, 2007)

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Temporary tolerance is achieved in hours and can be maintained if drug antigens are administered at regular intervals, depending on the drugs pharmacokinetic parameters [10]

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