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POSSIBLE SIDE EFFECTS Tirzepatide may cause the following side effects, especially at the beginning or with rapid dose escalation: Gastrointestinal (common, usually temporary): Nausea (up to 50% of users in studies)

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In Phase 2 trials, retatrutide was started at 12 mg subcutaneously once weekly and gradually titrated to maintenance doses of 4 mg, 8 mg, or 12 mg once weekly