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Figure 1 summarizes a conceptual overview rather than a single experimental model, developed on the basis of published evidence, with the aim of facilitating the understanding of central and peripheral pathways involved in the GI effects associated with GLP-1 receptor agonists

Moreover, sc semaglutide showed neuroprotective activity in a stroke animal model, improved motor control and muscle strength, and reduced infarct volume, loss of neurons, and inflammation [66]