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The demyelination in the olfactory bulb and tract were mirrored in nearby cortex layers but not deeper in the brain, suggesting to Joseph that perhaps the close proximity of the olfactory bulb/tract and the subjacent cortex provided an important clue, not only about the possible substrate for loss of smell in MS, but also about disease pathogenesis, he wrote in an email

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If your procedure is scheduled in the morning hours, then take the entire dose in the evening prior to the procedure