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Creatinine clearance was measured by 24hour urinary creatinine clearance measurements or estimated from serum creatinine based on the CockcroftGault formula: CrCl = [140 - age (years)] x weight (kg) [72 x serum creatinine (mg/dL)] Compared to normal healthy control subjects, an approximate 1.1- to 1.6-fold increase in plasma AUC of sitagliptin was observed in patients with mild renal insufficiency