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This in turn elevates HIF-1 levels, which act to enhance the expression of glycolytic enzymes and sustain a balance between Treg and pro-inflammatory Th17 cells by facilitating RORt-mediated transcriptional activation (8, 17)

Trends Genet 29:290 Orr MW, Mao Y, Storz G, Qian SB (2020) Alternative ORFs and small ORFs: shedding light on the dark proteome

It might not seem like the liver is doing a lot, but liver function impacts most systems in the body, and even mild liver problems can cause a big fuss