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and cellular respiration

PDE4 inhibitors, including CC-11050, CC-3052, and roflumilast, when combined with INH, have been shown to reduce the lung bacillary burden, lung pathology, and fibrosis, as well as the size and number of lung granulomas in M.tb -infected rabbits and in both acute and chronic TB mouse models [35, 108, 109]

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A 2001 systematic review of randomized, double-blind, placebo-controlled trials of thiamin in patients with DAT found no evidence that thiamin was a useful treatment for the symptoms of Alzheimer's disease (71)