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Compared with the metformin plus sulfonylurea combination, the lowest risk for all three investigated endpoints, namely MACE, severe hypoglycemia, and all cause-mortality, was seen for people treated with metformin in combination with SGLT2is and GLP-1RAs (HR, 0.53 [95% CI, 0.350.80] for MACE

Deckelbaum, R

This ensures that symptoms are not due to other conditions requiring different management, and establishes a baseline against which any changes after starting Wegovy can be assessed