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A Cox proportional hazards model was used to test for non-inferiority against the pre-specified risk margin of 1.3 for the hazard ratio (HR) of the composite of CV death, myocardial infarction (MI), or ischemic stroke (MACE) and if non-inferiority was demonstrated, to test for superiority on the two primary endpoints: 1) the composite of hospitalization for heart failure or CV death, and 2) MACE

As a Th2 effector, IL-31 correlates with itch severity and signals via IL-31 receptor alpha (IL-31RA)/Oncostatin M receptor beta (OSMR) receptors on sensory nerves to release calcitonin gene-related peptide and drive neurogenic inflammation (Lee et al., 2018)