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Speak with your doctor Kumar says patients should ask their physicians about what they see as the long-term plan for their weight-loss program and the continued role of medication in that, and consider the balance of medication versus lifestyle intervention as you progress through life

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Some patients take GLP-1 medication long-term as part of ongoing chronic disease management, while others may be able to taper off after reaching their goals particularly if they've built strong nutritional and behavioral habits during treatment

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FDA-approved options for chronic weight management include: Other GLP-1 receptor agonists (semaglutide, liraglutide) Combination therapies (phentermine-topiramate ER, naltrexone-bupropion ER) Orlistat Metformin for patients with diabetes or prediabetes, which provides modest weight-neutral or weight-loss effects Realistic expectations are essential

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