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Endotoxins activate specific membrane receptors termed Toll-like receptors that are members of a class of pro-inflammatory receptors hat recognize pro-inflammatory molecules termed pattern-associated molecular patterns or PAMPS that in turn can activate genes that initiate inflammatory cascades in the host [49, 65]

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Clinical advisories from endocrinology societies recommend prioritizing electrolyte-containing fluids over plain water, as semaglutide users often experience mild orthostatic effects during illness-related fluid losses

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