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Yes, Zepbound can be discontinued abruptly without causing withdrawal symptoms or requiring a gradual tapering schedule

Semaglutide has a longer half-life (approximately 7 days) compared to tirzepatide (approximately 5 days), which means the wearing-off effect is less pronounced with semaglutide

The more clinically important question is how often this produces meaningful perioperative harm, which patients are at highest risk, and how clinicians should balance aspiration prevention against the metabolic, cardiovascular, logistical, and equity-related consequences of withholding therapy

To date, no antenatal weight management tools have reduced the risk of adverse health outcomes for women with obesity and their offspring, resulting in a shift in focus to the pre-conception period