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For example, investigations in experiments in streptozotocin (STZ)-induced diabetic rats demonstrate that curcumin directly inhibits TGF-1induced Smad2/3 phosphorylation within renal cortical tissues, thereby reducing ECM accumulation in both glomeruli and the tubulointerstitium (127)

They are entirely different regulatory pathways with different standards

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Weight Management Programs: Structured programs that include diet, exercise, and behavioral support can be very effective