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Their expression is transcriptionally controlled by estrogen receptor (ER) and androgen receptor (AR), respectively ( 3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Table 1), suggesting that therapeutic targeting of ferroptosis may offer a promising strategy for the prevention and treatment of NDDs

Thus, we speculated that GLP-1-based therapies, especially liraglutide 25 , may be beneficial for the treatment of OA due to its anti-inflammatory and anti-catabolic effects as well as its potential analgesic properties when injected intra-articularly

doi: 10.1080/21505594.2022.2123325 10 CarvalhoF

Effects of Liraglutide Compared With Placebo on Events of Acute Gallbladder or Biliary Disease in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events in the LEADER Randomized Trial