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Without a loading dose, it would take months to achieve a therapeutic effect, which is likely clinically unacceptable

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Chemical penetration enhancers including propylene glycol, dimethyl sulfoxide (DMSO), and various terpenes increase GHK-Cu skin penetration by 2-4 fold, though potential irritation risks require careful optimization

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Elevated levels of GABAergic neurosteroids have been associated with hepatic failure, and it has been suggested that PregS may be of clinical benefit in the treatment of deficits in motor coordination and memory disturbances associated with hyperammonia seen in this patient population (245)

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