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Cartilage destruction is considered a hallmark of OA and is a result of increased production of catabolic effectors 32,33,34,35 and reduced matrix biosynthesis by chondrocytes 36

Similar to the fibular nerve the saphenous nerve boundary was recovered earlier, however, the saphenous nerve does not branch off of the sciatic nerve so sciatic nerve transection was not expected to affect the innervation of the saphenous nerve and all response to stimulus of the saphenous nerve was considered normal

Adipokines: adiponectin and leptin and their relationship with DPP-4 Adiponectin, another DPP-4 substrate hormone, is related to energy metabolism and is primarily secreted by brown adipose tissue and bone marrow adipose tissue [84]

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