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Lactobacillus and Bifidobacterium produce lactic acid and acetic acid that reduce intestinal pH, creating an unfavourable environment for the survival of pathogenic bacteria and suitable for the rebalancing of intestinal flora

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In normal trophoblast differentiation, the extravillous cytotrophoblast undergoes an epithelial-mesenchymal transition (EMT), during which epithelial cells loss some expressions of E-cad and dysregulations of EMT is associated with impaired trophoblast cells invasion and spiral artery remodeling [48]

Reactive nitrogen species in the respiratory tract