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However, the cornerstone principle remains: long-term success with either medication hinges on continued use

Key pathogenic pathways include increased intestinal permeability, which allows gluten peptides to cross the epithelial barrier and interact with immune cells, and the subsequent T-cell-mediated immune response

10.1089/ten.tea.2014.0416 102 HuangS.ChoiM

The levels of TRH, TSH, T 3 , and T 4 are regulated by a negative feedback system in which increasing levels of T 3 and T 4 decrease the production and secretion of TSH