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In brief, HUVECs were lysed in Co-IP buffer containing 20 mM Tris-HCl (pH 7.5), 100 mM NaCl, 0.5 mM EDTA, 0.5% NP-40, 0.5 mM PMSF, and 0.5% protease inhibitor cocktail on ice for 20 min

Aptamers, also known as chemical antibodies, are single-stranded oligonucleotides that shape a three-dimensional structure and bind to their targets just like antibodies [210]

The patient presented with mild alopecia and perioral, periorbital, and perigenital eruption

Our screening method can be employed in future searches for novel pharmacologic inhibitors, thus providing an approach for accelerating drug deployment, concludes the team