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Deficiency is widespread in the UK due to limited sunlight exposure, and is particularly prevalent in those with chronic illness, darker skin tones, or conditions affecting fat absorption

However, the lack of significant statistical interaction between subgroups (P = 0.127) suggests that addition of the AMPLITUDE-O trial has not changed the previous scenario [5], stressing that the net separation on MACE effect between patients with or without established CV disease may be more nuanced than suggested by previous meta-analyses [3]

Total daily dose: Weeks 14 at 500 mcg total , then Weeks 58 at 1000 mcg total , once daily (or 5 days on, 2 off)

Titration approach for muscle preservation Weeks 1-4: Start at 1mg weekly