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Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids

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Age Subgroups Statistically significant changes from baseline were seen in HbA 1c , BMI, and body weight across age subgroups for both formulations of semaglutide (Fig