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Interestingly, low blood levels of vitamin B12 have been linked with reduced bone mass, though clinical trials have not definitively supported the efficacy of B vitamin supplements in treating fractures ( Recent research states that the role of vitamin B12 and bone health is not well established

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Similar to P-gp, ABCG2 is a drug-resistant semi-transporter on the tumor cell membrane, which also acts as a drug pump and is closely related to the accumulation of drugs in cancer cells

However, detailed results from these trials have not been published in peer-reviewed journals, limiting comprehensive assessment of clinical efficacy