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Once someone has done all the right things for nutrition, fitness, sleep, stress management, and frailty prevention, then having a conversation about adding a pharmacologic option for longevity or optimization becomes appropriate. The Takeaway GLP-1 medications, like semaglutide and tirzepatide, were originally developed for diabetes, but researchers are now exploring if they may extend lifespan and help people maintain good health for a longer period of time

Limited data from small observational and retrospective studies suggest the safety and efficacy of tirzepatide in these populations, illustrating the need for dedicated clinical trials.209 Additionally, the potential neuroprotective effects of tirzepatide remain unclear

If obesity is better understood as a problem of fat trapping, a neuroendocrine fuel-partitioning disorder rather than an energy balance problem, that has profound implications for not just the treatment of obesity but for its prevention