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According to the FDA's approval announcement , patients across the three doses lost significantly more weight than those on placebo, with the higher doses producing the largest reductions, averaging around 1821% of body weight at the top dose over 72 weeks in the trial of adults without diabetes

The study showed that among participants with obesity and knee osteoarthritis with moderate-to-severe pain, treatment with once-weekly injectable semaglutide 2.4 mg resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis than placebo