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Peter Attia, a longevity physician, discusses NAD+ precursors: "While evidence is emerging, NAD+ boosting shows promise for mitochondrial health and longevity, though IV might not be optimalprecursors like NMN could be better."[33][20] On combinations, he cautions on long-term data but notes potential for metabolic disorders

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Both local application (directly at the injury) and systemic intramuscular injection proved effective

Studies of topical use have reported improvements in skin density, thickness, and appearance of fine lines over 12-week windows, with a well-documented safety profile at typical cosmetic concentrations (Borkow, Using Copper to Improve the Well-Being of the Skin, 2015)