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Only Trp is statistically more conservative than Cys

Glutathione (GSH) Key Research Facts Chemical identity: Tripeptide gamma-glutamyl-cysteinyl-glycine (Glu-Cys-Gly) Molecular weight: 307.32 Da (reduced form, GSH) Cellular concentration: 110 mM in cytosol

Thus, a combination of low cysteine concentration, a high demand across multiple cellular processes and oxidative stress mediated by a reduction in GSH probably explains the amplified transcriptional response to cysteine deficiency compared with other amino acid deficiencies

It may also help older patients who want to maintain joint function and daily mobility