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GLP-1 may nevertheless also directly inhibit glucagon secretion, because -cell-specific GLP-1R KO mice have elevated non-fasting glucagon levels relative to wildtype controls and female -cell-specific GLP-1R KO mice are mildly glucose intolerant with increased secretion of glucagon upon peripheral administration of glucose [607]

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The 2025 Nobel Prize in Physiology or Medicine is awarded to Joel Habener, Svetlana Mojsov, and Jens Juul Holst for their discovery and development of GLP-1based therapeutics, which have revolutionized the treatment of diabetes and obesity worldwide. Well

Y agreg que la llegada de estos medicamentos representa un punto de inflexin en el tratamiento de la obesidad