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Hypersensitivity reactions and allergies Although a mild rash and itching at the injection site are common reactions, more serious issues like hives and eczema are possible

Mechanistically, the authors reported that the uremic toxin, indoxyl sulfate, activates the aryl hydrocarbon receptor (AhR), and experiments using AhR knockout mice confirmed that AhR activation is a key driver of BBB damage (Bobot et al., 2020)

5 Conclusion This systematic review and meta-analysis indicate that sublingual and oral vitamin B12 administration provide efficacy comparable to intramuscular injection in improving serum cobalamin levels and reducing hyperhomocysteinaemia

[3] Liver and Detox Support Plays a central role in the bodys natural detoxification processes