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Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]

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In 1990, a Canadian endocrinologist first isolated Exendin-4 from a Gila monsters saliva

Sequencing and Combination Use of SGLT2is and GLP-1 RAs There was agreement that sequential or upfront combination therapy with SGLT2is and GLP-1 RAs is appropriate for individuals with ongoing kidney progression, high cardiovascular risk or suboptimal metabolic control