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As for CASP3, studies have shown a correlation between abnormal expression and BRCA patient prognosis, and an abnormal CASP3-mediated apoptosis pathway is a potential mechanism of chemoresistance in BRCA 40,41

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In support of their lawsuits, plaintiffs point to a recent study by the European Medicines Agency (EMA) that indicated that the drugs product information should be updated to include warnings of the risk of developing NAION

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