(221) have emphasized the significant impact of hypogonadism in PWS, leading to issues such as genital hypoplasia, incomplete pubertal development, and infertility in most cases
In the case of mass spectrometry (MS)- based metabolomics, several strategies are use, e.g., desorption electrospray ionization mass spectrometry (DESI-MS) or flow injection analysis-MS (FIA-MS), or in combination with separation techniques such as gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), or capillary electrophoresis-MS (CE-MS), to increase separation and better identification and quantitation of the metabolites present in a cell extract (Pitt, 2009
Production, isolation, structure determination and biological activities
[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Henner R.L., Keshavan M.S., Hill K.P