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Yes, GLP-1s have been used safely in women over 40, including those in perimenopause or menopause

GLP-1 medications, or glucagon-like peptide-1 receptor agonists, treat type 2 diabetes when other medications havent sufficiently managed blood sugar levels

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Glutathione monoethyl ester (5 mM) prevents Ethacrynic acid (HY-B1640)induced GSH depletion, ROS accumulation, and TDP43 nuclear clearance within 5 h, and restores GSH levels, reduces oxidative stress, prevents cell death, and normalizes TDP43 localization and GAPDH expression within 72 h in mouse motor neuronlike NSC34 cells [2]