Crocetin simultaneously increased serum NO levels, upregulated vessel mRNA expression of eNOS, and vessel cyclic GMP (cGMP) content
revealed that just ten minutes of acute physical activity can trigger thousands of molecular changes related to inflammation, energy metabolism, oxidative stress, and so on [43]
In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
However, as we age, or when we face high levels of stress and poor nutrition, our natural production of glutathione often declines