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This is where genetic insights become valuableyour body's response to GLP-1 therapy is partly determined by variants in appetite-regulation genes

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However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists

It is to be noted that the best data for MOTS-c to date comes from cell and animal studies