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Through local delivery, medication concentrations in the lungs can be increased while systemic side effects can be decreased

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As mentioned before, IF is beneficial for nervous system by cellular, metabolic and circadian mechanisms and a promising therapy for brain disorders, future research should disentangle whether positive effects of IF could be applied in clinical situations (61)

NF-B not only induces canonical pro-inflammatory cytokines (TNF-, IL-6, pro-IL-1) but simultaneously up-regulates facilitative glucose transporter, metabolically locking macrophages, DCs and activated T cells into a glycolytic, NO-rich phenotype that fuels chronic mucosal inflammation (110112)