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Murphy JM, Henry RG, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C (2007) Continuum of frontal lobe impairment in amyotrophic lateral sclerosis

Direct and indirect biomarkers are used as follows: Lipid peroxidation: Malondialdehyde (MDA) is measured via the Thiobarbituric Acid-Reactive Substances (TBARS) assay, while F 2 -isoprostanes (stable end-products of arachidonic acid oxidation) are quantified by gas or liquid chromatography-massmass spectrometry (HPLC/MS-MS) for high specificity (Sabitha et al., 2024)

It will grow to $18.32 billion in 2030 at a compound annual growth rate (CAGR) of 5.4%

Brief periods of 30 to 60 minutes for dose preparation are fine