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Usage in Pregnancy Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus

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Melatonin decreases the expression of the estrogenic receptor and restricts the binding of the estradiol complex to the estrogen response element on DNA (Lopes et al