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Studies have highlighted the role of persistent fibrosis in aged tissues, where myofibroblasts in injured tissues of aged mice acquire a sustained senescent and apoptosisresistant phenotype, exacerbating fibrosis (Hecker et al ., 2014)

C-Reactive Protein (CRP) A study on the effects of non-surgical periodontal treatment on serum CRP levels found that systemic inflammation in patients with CKD resulted from periodontitis (Yazdi et al., 2013)

GLP-1 receptor agonists have shown strong efficacy in lowering blood sugar levels, reducing HbA1c, and promoting substantial weight loss in affected patients

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