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Finally, beware of compounded GLP-1 drugs, which became popular during a GLP-1 drug shortage starting in 2022

The cAMP/PKA pathway inhibits voltage-gated potassium channels that respond to depolarization, opens and allows K + efflux, repolarizing the cell and allowing increased calcium influx through voltage-dependent calcium channels, resulting in the exocytosis of insulin from -cells (115)

According to the company, providers can modify dosage at any time based on medical history, progress, and weight loss goals

Several key areas where further research could better inform future consensus reports were of particular interest to the writing group