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A study conducted using a rat model of type 1 diabetes demonstrated reduced inflammatory cell infiltration and decreased glomerular expression of inflammatory markers, including TGF-1 and intercellular adhesion molecule-1, with administration of exendin-4 [51]

In practice, doctors also weigh comorbidity, prior treatment, contraindications, and whether long-term follow-up can be done safely

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Retatrutide's novel triple-agonist mechanism could trigger an advisory committee a first-in-class mechanism warrants external expert input