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Chiu CN, Rihel J, Lee DA, Singh C, Mosser EA, Chen S, Prober DA (2016) A zebrafish genetic screen identifies neuromedin u as a regulator of sleep/wake states

This represents a distinct failure mode that cannot be addressed solely through formulation optimization

These separate, but related mechanisms of action of an amylin-analog and a GLP-1 receptor agonist appear to have an additive effect on appetite reduction