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doi: 10.3389/fmolb.2022.859760 121 SapoK.MakaR.JanasT.JanasT

Meldonium, an analogue of GBB, significantly decreased gut microbiota-dependent TMA/TMAO production from L-carnitine in Wistar rats (Kuka et al., 2014)

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Targeting these amino acid-driven metabolic circuits may offer novel therapeutic opportunities in fibrotic diseases such as IPF, where metabolic vulnerabilities can be exploited to disrupt fibroblast activation and excessive ECM remodeling