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[100] The limited available data suggests that the likelihood of excessive use of e-cigarettes is smaller than traditional cigarettes

One of the main differences between these choices, is the population considered: on one side, health protection is focused on the relative risk of cigarette for non-smokers, on the other side, the harm reduction principle aims to help the people affected by conventional tobacco smoke

In addition, in case of testing the difference between three groups (COPD GOLDII patients or COPD GOLDIV patients relative to non-COPD patients), we used a one-way ANOVA and a Dunnetts post-hoc test for multiple comparisons (normal distribution) or a KruskalWallis test followed by a Dunns multiple comparisons test (non-normal distribution)

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