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Abstract Glucagon-like peptide-1 receptor agonist (GLP-1RA), a novel hypoglycemic agent for the treatment of type 2 diabetes, has well-known effects such as lowering blood sugar, ameliorating inflammation, reducing weight, and lowering blood lipids

This activation then triggers the transcription of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) gene, causing podocyte pyroptosis and contributing to the development of DKD[36]

NAM, a metabolite in the salvage pathway, is reduced in both CSF and serum from ALS patients compared with healthy people

La L-carnitina tiene un papel importante en el metabolismo energtico, 8 ya que se encarga de facilitar la entrada de los cidos grasos de cadena larga en la matriz mitocondrial, donde son oxidados y se transforman en energa