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It is interesting to note that the positive effect of tirzepatide on body weight is associated with a significant improvement in quality of life and physical performance [50] and is independent of sex [51], baseline body mass index (BMI) [52] and potential side effects, predominantly gastrointestinal [53]

Most people tolerate both medication types well after initial adjustment

For patients with unusual weight (such as morbid obesity), it may be helpful to check a phenobarbital level 2 hours after the initial loading dose (to confirm an adequate level was achieved and to calculate V D )