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The reversal of NET function results in efflux of cytoplasmic norepinephrine, normally contained in the , readily releasable pool 12) into the synaptic cleft, independent of calcium influx and the normal process of vesicular release (Raiteri and Levi, 1986

These potential benefits make it a promising option for those looking to optimize their health and vitality

While this HLST muscle-strengthening program can be used in conjunction with other prescribed PF therapies (eg, weight loss, other types of stretches, nonsteroidal anti-inflammatory drugs, and other treatments noted in the introduction), it can also be considered a stand-alone therapy to treat the symptoms of PF

Thus, evidence from experimental animal models has generally supported the presence of increased paracellular permeability in hypertensive models