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The mean SD plasma nicotine concentrationtime profiles following single oral product use of various nicotine products under fasting conditions in adult smokers are displayed in Fig

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A Cochrane systematic review found that smoking cessation was associated with a 36% reduction in the risk of long-term all-cause mortality in patients with established CVD (Critchley & Capewell, Reference Critchley and Capewell2004) whilst a large individual patient meta-analysis of data from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium (Mons et al., Reference Mons, Muezzinler, Gellert, Schottker, Abnet and Bobak2015) demonstrated that smoking cessation reduces smoking related cardiovascular risk continuously over time